Low Intensity Pulsed UltraSound (LIPUS)

The LIPUS Project concerns the use of ultrasound for the stimulation of chondrosytes (mesenchymal stem cells) for the production and maintenance of cartilaginous matrices in tissue engineering. Normally an ultrasound frequency of around 1.5 MHz with a power density of around 30 mW/cm2 is used. Alternative frequencies, pulse widths and pulse durations remains relatively uninvestigated. To make this possible, an array of power amplifiers with adjustable parameters has been developed.

In addition, a means of individual sample measurement (ultrasound intensity and temperature) is necessary. As an alternative to very expensive hydrophones, other more cost effective methods are being investigated.